Publikationen zum Thema Spiroergometrie


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  • Nr Titel Autoren/Institut Segement Produkt
  • 2015-025 Clinical Significance of a Spiral Phenomenon in the Plot of CO2Output Versus O2Uptake During Exercis Nagayama, Osamu; Koike, Akira; Himi, Tomoko; Sakur
Produktbereich: Medizin
Veröffentlichung: Article
Sprache: English
Verlag/Herausgeber: The American Journal of Cardiology, March 2015, Vol. 115 Issue: Number 5 p691-696, 6p

Abstract:
A spiral phenomenon is sometimes noted in the plots of CO2output (VCO2) against O2uptake (VO2) measured during cardiopulmonary exercise testing (CPX) in patients with heart failure with oscillatory breathing. However, few data are available that elucidate the clinical significance of this phenomenon. Our group studied the prevalence of this phenomenon and its relation to cardiac and cardiopulmonary function. Of 2,263 cardiac patients who underwent CPX, 126 patients with a clear pattern of oscillatory breathing were identified. Cardiopulmonary indexes were compared between patients who showed the spiral phenomenon (n = 49) and those who did not (n = 77). The amplitudes of VO2and VCO2oscillations were greater and the phase difference between VO2and VCO2oscillations was longer in the patients with the spiral phenomenon than in those without it. Patients with the spiral phenomenon also had a lower left ventricular ejection fraction (43.4 ± 21.4% vs 57.1 ± 16.8%, p <0.001) and a higher level of brain natriuretic peptide (637.2 ± 698.3 vs 228.3 ± 351.4 pg/ml, p = 0.002). The peak VO2was lower (14.5 ± 5.6 vs 18.1 ± 6.3, p = 0.002), the slope of the increase in ventilation versus VCO2was higher (39.8 ± 9.5 vs 33.6 ± 6.8, p <0.001), and end-tidal PCO2both at rest and at peak exercise was lower in the patients with the spiral phenomenon than in those without it. In conclusion, the spiral phenomenon in the VCO2-versus-VO2plot arising from the phase difference between VCO2and VO2oscillations reflects more advanced cardiopulmonary dysfunction in cardiac patients with oscillatory breathing.

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